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KMID : 0374019920150030245
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Ewha Medical Journal
1992 Volume.15 No. 3 p.245 ~ p.252
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An Experimental Study for Histopathologic Changes of Rat Urinary Bladder Due to Intravesical Bacillus Calmette-Guerin Instillation
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Abstract
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The Bacillus Calmette-Guerin(BCG) instillation of urinary bladder as a treatment of superficial bladder tumor can cause inflammatory changes in non-neoplastic area. Which occasionally gives difficulty in differentiation from recurrent tumor on
follow-up
cystoscopy. This study was performed to see the changes of non-neoplastic bladder wall according tot he dosage of BCG and time intervals. Low dose(8×10E6 CFU/ml) and high dose(12×10E6 CFU/ml) as well as normal saline were instilled into bladder
of
female Wister rate. The histopathological examination was performed on 1. 2. 4 and 8 weeks. Respectively.
@ES The following results were obtained:
@EN 1) On 2 weeks after intravesical BCG instillation. Chronic inflammation with lymphocytes infiltration was noted on the bladder mucous and muscular layer. But tuberculous granuloma was not observed. There was not significant difference between
Group
I and Group II.
2) Chronic inflammatory changes were continuously progressed till 8 weeks. And more severe in Group II than Group I.
3) The denudation of ulcerative epithelial cell was noted in only one case of Group II.
The above results suggest that histopathologic change after BCG instillation on non-neoplastic area was remained upto 8 weeks and need further evaluation for long term effects.
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KEYWORD
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